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History The first reports of the handling of this plant date back to the year 500 of the contemporary era, but it is speculated that its cultural use dates back much earlier thanks to the archeological findings found in the province of Bautista Saavedra in Bolivia inside a multifamily tomb, where bags with carefully prepared guayusa leaves were found along with other instruments such as enemas, trays and snuff tubes, a human skull, spatulas, and mortars, among others, presumably belonging to a healer of the Kallawaya or Tiwanaku ethnic group [2,40]

10.1016/j.bmcl.2013.01.099 Bioorg

Senior author Izzuddin Aris, associate professor at Harvard Medical School and the Harvard Pilgrim Health Care Institute, said: Our study shows that heart health in midlife is shaped by more than personal choices

This reflects the medical understanding that obesity involves persistent metabolic, hormonal, and neurological changes that often require ongoing pharmacological intervention