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This approach combines medication with dietary guidance, exercise recommendations, and behavioral support to ensure long-term success

The US obesity rate, after decades of unstoppable growth, has at last started to plateau, but at a level that continues to lead the developed world

In the 1950s, epigenetics was defined when a remarkable fact was uncovered: genetic activity could be changed without altering DNA.2 This change could occur in the short term and be temporary or permanent, or, in some cases, it could be passed on to a persons offspring

The limitations of this work are that we included RCTs, non-RCTs, and observational studies, which may lower the overall quality of evidence of the included studies