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It is hypothesised that both the anti-tumour response and the development of irAEs are representative of a robust immune reaction, where self-reactive T cells infiltrate both tumours and the organs that develop irAEs

These form a protective membrane around the contents, allowing improved absorption

doi: 10.1002/mnfr.202101019, 26

Growth hormone elevation can also increase blood pressure and glucose in some patients, potentially offsetting tirzepatide's glucose-lowering benefit if not monitored