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In some research contexts, periodic breaks may actually enhance outcomes by allowing receptor upregulation during rest periods, improving responsiveness when dosing resumes

Once intakes of 2.5mg/d are reached, excretion becomes approximately equal to the rate of absorption (Horwitt et al., 1950)

doi: 10.3389/fendo.2023.1237882 Received 10 June 2023 Accepted 11 September 2023 Published 18 October 2023 Volume 14 - 2023 Edited by Elnaz Daneshzad, Tehran University of Medical Sciences, Iran Reviewed by Hadis Fathizadeh, Kashan University of Medical Sciences, Iran