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Theoharides and his team note that mast cells can be stimulated by the autonomic nervous system (ANS) and that the ANS can also affect the release of neurosensitizing, proinflammatory, and vasoactive mediators by mast cells

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However, the new cartilage created by FOXO4-DRI pretreated PDL9 cells indeed displayed reduced expression of several SASP factors, implying the benefit of FOXO4-DRI pre-treatment in enhancing the cartilage quality