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Loading Phase Some individuals may undergo a loading phase initially, involving more frequent injections to quickly elevate B12 levels in the body

How well the body absorbs B12 depends on age, gut health, and medical conditions

Additional medical evaluation may be necessary for: A physician-guided consultation helps determine whether peptide therapy is appropriate based on medical history, current medications, and individual wellness goals

This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice