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Collectively, the STEP program and related studies show: Average weight loss of around 1517% of initial body weight over about 68 weeks with semaglutide 2.4 mg once weekly, alongside lifestyle changes

The TriNetX platform also only reports population-level results (no access to individual patient data) and uses statistical blurring, reporting all population-level counts between 1 and 10 as 10

The medication also slows gastric emptying, which means that food, including carbohydrates, moves more slowly from the stomach into the small intestine where absorption occurs