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FFA extraction increases

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A C18 fatty-diacid chain promotes reversible albumin binding and resistance to DPP-4 degradation, extending the plasma half-life to roughly 7 days and enabling a once-weekly dosing profile in research models

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Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity, New England Journal of Medicine (2025), DOI: 10.1056/NEJMoa2502081,

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