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As described in the CY 2023 PFS final rule, a number of factors informed our proposal and decision to finalize the current approach that allows eligible ACOs to participate for a 5-year agreement period under Level A of the BASIC track with the opportunity to enter a second agreement period under the BASIC track's glide path beginning under a one-sided model

Dihexa pharmacological parameters Pharmacokinetic Parameter Mean SEM AUC0- (min^g/mL) 4471 1408 Vd (L/kg) 54.4 14.8 CpO ^g/mL) 87.3 31.9 tl/2 (min) 18256 7787 KE (min- l ) 0.00007 0.00004 CL (L/min/kg) 0.0026 0.0007 N=3 Table 10

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Ning, H