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Tolerance In other instances, the medication may have worked at least initially but it doesnt seem to be working as well anymore

Other supplements have variable potency and are poorly absorbed

The nervous system can quickly develop tolerance to the drug

Common side effects include: Gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation) Decreased appetite and potential malnutrition in vulnerable individuals Risk of hypoglycemia when combined with insulin or sulfonylureas Rare but serious risks including pancreatitis and gallbladder disease Important safety considerations include: Boxed warning for thyroid C-cell tumors in rodents