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We exploited this methodology to systematically examine transducer engagement for 15 different pathways (G s , G q , G 11 , G 14 , G 15 , G 12 , G 13 , G i1 , G i2 , G i3 , G oA , G oB , G z , G protein-coupled receptor kinase (GRK)/G and ARR (Fig

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