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FOXO4 should be capable of continuing to play a vital role in the transcription of genes for antioxidant enzymes, such as manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX)

Iron release from ferritin is dependent on lysosomal activity in a process termed ferritinophagy [19]

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It was expected to find an increase in lactate production as a result of acute myocardial ischemia, which blunts the mitochondrial oxidative phosphorylation and leads to an increase in anaerobic (glycolytic) metabolism generating pyruvate and then lactate