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In June 2024, the FDA officially approved tirzepatide for the treatment of obesity-associated OSAS, marking the first GLP-1based therapy worldwide to receive this indication (16)

The fat-free mass (equation [14]) should be considered rather than total body weight for obese patients, and correction should be made for muscle wasting in severely ill patients

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Prism (v.10.0.3) software was used to calculate P values using a two-sided MannWhitney test, two-sided unpaired t -test, KruskalWallis test with Dunns post-test, one-way ANOVA, two-way ANOVA or MantelCox log-rank test as indicated