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The analysis focused on the KEGG 2021 Human and Reactome 2022 gene sets, with a P -value cut-off of 0.05

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February 2026: Eli Lilly reported that orforglipron, its once-daily oral GLP-1 receptor agonist, is being evaluated in Phase III studies for weight management in adults with obesity or overweight with at least one weight-related medical condition

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