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Enhanced expression of GSH metabolism enzymes including glutathione peroxidases, gamma-glutamyl cysteinyl synthetase (gamma-GCS), glutathione S-transferases (GST), and ABC-family membrane transport proteins including the multidrug resistance-associated protein (MRP) were all documented to play prominent roles in cellular resistance to oxidative stress

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Also it has been found that a loss of E-cadherin such as is observed in invasive lobular breast carcinoma (ILC) results in increased expression and activity of the IGF-1R pathway (Nagle et al., 2018)