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Following an apoptotic stimulus, Bax is activated and translocates to the mitochondria, where it undergoes a conformational change and inserts into the OMM

Interestingly, loss of muscle mass in itself appears not to be associated with functional decline and disability [51] but rather maintenance of muscle strength is key to preventing functional decline [52], with randomised controlled trials (RCTs) demonstrating the benefit of resistance training in older adults [53]

Moreover, ferroptosis in this cell line can be assessed using the classic cytotoxic lactate dehydrogenase (LDH) assay (see figure)

Genome-wide and candidate-region studies reveal global DNA hypomethylation and locus-specific changes in peripheral blood, enriched for stress-response, immune-inflammatory and central-sensitization pathways