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Semaglutide activates GLP-1 receptors throughout the body in the pancreas, gut, and critically in the brain, particularly in the hypothalamic arcuate nucleus and reward-processing regions of the mesolimbic system

In addition to suppressing appetite, boosting insulin secretion and slowing stomach emptying, these drugs appear to influence brain pathways involved in food reward and cravings, making them a potential candidate for tackling the loss of control that characterizes binge eating

(9) If more research finds that retatrutide is both effective and safe for the treatment of fatty liver disease, this may provide another drug-based treatment option in the future

[2] NICE does recommend liraglutide (Saxenda) as an option for managing overweight/obesity in adults in Tier-3 services and with specific BMI criteria (TA664)