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Why it's relevant to psoriasis: Directly inhibits NF-B activation (central to psoriatic inflammation) Reduces pro-inflammatory cytokine production Used in inflammatory bowel disease research (similar immune dysregulation) No melanin-related effects unlike full alpha-MSH Research context: KPV has shown efficacy in reducing gut inflammation in colitis models

Next, we compared fold changes (FCs) relative to medium control (RPMI) in metabolite levels in monocytes exposed to Bb with cells exposed to the TLR4 ligand LPS and the TLR2 ligand Pam3Cys

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