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GIP can stimulate the first phase of GLP-1 secretion independent of the vagus nerve, but only when infused at suprapharmacological levels, as evidenced by the rapid rise and fall in plasma GLP-1 upon supraphysiological infusion of GIP in sham and vagotomized rats (Rocca and Brubaker, 1999)

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coli carrying either the empty vector () or the vector encoding the C-terminal region of SyeA (His6-SyeA), uninduced and induced at 0.05 mM IPTG