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A166 is another HER2-based ADC, containing the antimicrotubule Duostatin-5 payload conjugated via a stable protease-cleavable valine citrulline linker

C.Sanchez-CalvoB.ValderramaR.et al (2013)

Lipid bilayer was placed at centre in a rectangular periodic box filled with TIP3P water and ZIL (with 8716 and 32 molecules, respectively), where the buffer size between the edges of the box and the lipid model was set at around 34 , and the MD simulation of cell membrane in 5 wt% ZIL aqueous solution was carried out using Amber18 and AmberTools19 software 31

Every time you draw from your reconstituted vial, quick visual inspection tells you whether the solution likely remains active