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Because research-grade material is of unverified identity and purity, identity confirmation (for example by mass spectrometry and HPLC) is the kind of characterization a rigorous research setting would require before drawing any conclusion

Unexplained anemia: Particularly in a specific form (megaloblastic anemia) where the red blood cells are enlarged, a vitamin B12 deficiency is a common cause

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This was because the drug did not significantly reduce weight in 536 subjects over the course of 24 weeks 2