EN is associated with prolonged hospitalization and high healthcare costs.3 The most important aspect of EN treatment is discontinuation of treatment with the causal agent, admission to a specialist intensive care unit with experience in managing this condition, and provision of appropriate support measures.4 Treatment of EN is the subject of some controversy: corticosteroids, classical immunosuppressants, monoclonal anti-TNF- agents, immunomodulators such as immunoglobulins, and plasmapheresis have all been used without clear evidence of effectiveness
Cell Death Dis 10:523 Xue C, Gu X, Li G, Bao Z, Li L (2020) Mitochondrial mechanisms of necroptosis in liver diseases
Due to the risk of respiratory depression with concomitant use of muscle relaxants and opioids, consider recommending or prescribing an opioid overdose reversal agent (see WARNINGS)
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