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REDEFINE-1: adults with obesity, no diabetes Design: 3,417 adults with BMI 30 (or 27 with a comorbidity), without type 2 diabetes, for 68 weeks

estimated ~41% direct, weight-loss-independent effect.) Wang L, Xu R, Kaelber DC, Berger NA

But that is not universal

The suppression of antioxidants might influence triiodothyronine (T3), thyroxine (T4), and neurotransmitter noradrenaline and elevate sperm DNA fragmentation (60)