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In attention-deficit/hyperactivity disorder populations, meta-analyses and large registry-based studies consistently demonstrate modest, dose-dependent increases in heart rate ( 510 bpm) and systolic blood pressure ( 25 mm Hg) with amphetamine or methylphenidate use, but no clear increase in major adverse cardiovascular events in otherwise healthy children and adults [89,90,91]

[DOI] [PMC free article] [PubMed] [Google Scholar] Neilands J

These PCs significantly lowered fasting blood glucose, improved glucose/insulin tolerance, and optimized lipid profiles (total cholesterol, triglycerides, LDL cholesterol), while reducing oil-red staining in hepatic and serum tissues

[DOI] [PubMed] [Google Scholar] Saghafian F, Malmir H, Saneei P, Milajerdi A, Larijani B, Esmaillzadeh A