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Dihexa binds to the HGF receptor c-Met with high affinity, and once bound, it triggers intracellular signaling cascades (primarily PI3K/Akt and MAPK/ERK pathways) that remain active for hours beyond peptide clearance

Gastroprotective Aspects of Synthetic Peptides: A Focus on BPC-157 in Preclinical Studies

0.1% (placebo) Steady State: Achieved after 4-5 weeks of weekly dosing Safety: Nausea (68% at 4.5 mg), vomiting (32%), generally mild-moderate and transient Discontinuation: 14% discontinued due to GI adverse events Appetite Effects: Significant reductions in Visual Analogue Scale (VAS) hunger scores Publication: Lau DCW, et al

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