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Therefore, conjugation with GSH is an important protective mechanism against reactive electrophilic xenobiotics, such as environmental pollutants, chemical carcinogens, antitumor agents (adriamycin, busulfan, chlorambucil, c/s-platin, cyclophosphamide, ethacrynic acid) preventing their covalent binding to proteins

10.1016/j.jri.2024.104271 10 DollS.ConradM

Current experiments rely on SOD1 transgenic models, which do not recapitulate mitochondrial complex IV deficiency or the genetic heterogeneity of sporadic ALS (such as C9orf72 repeat expansion) and do not assess spinal cord targeting or pharmacokinetic limitations of ferroptosis inhibitors, including low solubility and short half-life

EGFR is a transmembrane receptor tyrosine kinase that relays extracellular signals to intracellular signalling pathways and plays a critical role in cellular communication and function