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BMC Complement Altern Med 19:18 Qiu H, Fu P, Fan W, Zuo C, Feng P, Shi P, Cao L, Liu F, Zhou L, Chen F (2014) Treatment of primary chronic glomerulonephritis with Rehmannia glutinosa acteosides in combination with the angiotensin receptor blocker irbesartan: a randomized controlled trial

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The most impressive structural feature of peptide 20 is the lipidated K10 P by a 16-carbon palmitic acid through a -carboxylate spacer, which perfectly inserted into the TM1-TM2 crevice and made extensive contacts with both receptors and lipid membrane to stabilize the binding poses (Fig

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