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(Kwak 2014) 40 patients with SIBO and systemic sclerosis were assigned into three groups with antibiotics and/or probiotics twice per day for two months: metronidazole (M

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4) Systemic anti-inflammatory effects (and why that matters) A growing body of research suggests GLP-1 therapies may have anti-inflammatory and vascular benefits , including improvements in markers of systemic inflammation and endothelial (blood vessel) health

However, the aggressive caloric deficit it enables can indirectly suppress testosterone through the HPG axis, as the body reduces reproductive hormone production in response to energy restriction