One recent analysis of six years of medical records from the Department of Veterans Affairs, which reviewed the records of 2 million patients with diabetes, found that those taking a GLP-1 agonist medication had a reduced risk of developing dementia, including Alzheimers, as well as psychiatric and substance use disorders, though it also found an increased risk of gastrointestinal disorders, kidney stones, and pancreatitis
According to the Ozempic Summary of Product Characteristics (SmPC), injection site reactions are classified as 'uncommon', meaning they affect between 1 in 100 and 1 in 1,000 patients (trial rates were typically below 1%)
NNMT Inhibition The primary mechanism of 5-Amino-1MQ is selective inhibition of nicotinamide N-methyltransferase (NNMT)
After six weeks of intervention, exenatide increased the incidence of smoking abstinence by 19.5%, demonstrating higher posterior probability compared to placebo (PP = 96.5%) [26]