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Studies show that female rodents have higher mitochondrial GSH levels and antioxidant enzyme activities, linked to estrogen-mediated activation of MAPK and NF-B signaling pathways, suggesting sex-based differences in redox resilience (37-39)

Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC MS/MS

That framing has slowly shifted as the FDA began classifying severe obesity as a chronic disease and as the clinical evidence for GLP-1 receptor agonists in cardiovascular risk reduction accumulated [1]