A 45-year-old with obesity, prediabetes, and hypertension might benefit more from aggressive weight loss and metabolic normalization than from Metformins proven but modest effects
doi: 10.3389/fchem.2025.1536858 Received 29 November 2024 Accepted 27 January 2025 Published 19 March 2025 Volume 13 - 2025 Edited by Federica Aureli, National Institute of Health (ISS), Italy Reviewed by Eric Deconinck, Sciensano (Belgium), Belgium Maria Cristina Gaudiano, National Institute of Health (ISS), Italy Updates Copyright 2025 Blazewicz, Poplawska, Daniszewska, Piorunska and Karynski
PMID: 25006142, PMCID: PMC5459394, DOI: 10.1377/hlthaff.2014.0053
Our previous study showed that the glutathione metabolism pathway and the activity of GR was induced under hyposaline stress (Wang et al., 2019a