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It varies by person

Another SURMOUNT-3 analysis208 demonstrated that tirzepatide improved health-related quality of life scores in obese/overweight adults, with greater benefits observed in those achieving higher weight loss thresholds and in those without baseline functional limitations

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis

Regarding skin lesions, bullous pemphigoid, a rare autoimmune skin disease, was found to be associated with the use of DPP-4 inhibitors in a retrospective analysis of more than 9,000 patients treated in Japan during the years 20092017