doi: 10.1210/jc.2006-1075 71 CanarisGJManowitzNRMayorGRidgwayEC
IL-1Ra knockout in mice led to accelerated IDD, represented by decreased proteoglycan, disrupted collagen structure, increased matrix-degrading enzymes, including MMP3, MMP7, and ADAMTS4, 144 and a higher histological grade of degeneration
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