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Guo P, Deng Y

MATLAB (Release 2021b, The Mathworks, Inc., Natick, MA, USA) was used to generate plots

Furthermore, increased circulating levels of Ang II disrupt blood-brain barrier (BBB) integrity, allowing circulating Ang II to access the brain parenchyma and trigger the AT 1 R directly, producing oxidative stress and brain inflammation ( 2 R is activated by Ang II and may counterbalance AT 1 R neurotoxic effects and determine a neuroprotective role in RAS activation, such as vasodilation, diuresis, anti-fibrosis, antihypertensive, and cognitive improvement

3.3 SARS-CoV and SARS-CoV-2 Infection Recent studies also highlighted the importance of disulfide-thiol balance in the viral entry of coronaviruses SARS-CoV and SARS-CoV-2