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Open questions What are the therapeutic targets or strategies suitable for the various diabetic complications

For example, if you are having your iron levels checked, eating an iron-rich meal like red meat or fortified cereal right before your test can temporarily and artificially increase your iron levels

While current studies have delineated the core roles of ferroptosis (via the System Xc GSHGPX4 axis, iron overload, lipid peroxidation, and mitochondrial dysfunction) and identified antioxidant networks (Nrf2/Sirtuins/FTH1) as therapeutic targets in DN, several critical research gaps persist that hinder a comprehensive understanding of ferroptosis-driven DN progression and translational application

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