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If successful, GLP-1 RAs like semaglutide could transform HFpEF management by addressing weight-related and cardiometabolic issues, preventing progression to HFrEF

The medication takes time to cause significant weight loss and improve blood sugar levels

In experimental settings, it supports research into: Hormone-mediated regulation of glucose uptake Cellular energy utilization pathways Lipid metabolism and signaling networks Receptor cross-talk and intracellular signaling cascades Its multi-agonist nature makes it ideal for studying complex endocrine feedback mechanisms and systems-level metabolic regulation

The clinical classification follows the WHO categorization, covering PAH, PH associated with left heart disease (Group 2), PH associated with lung diseases/hypoxia (Group 3), chronic thromboembolic pulmonary hypertension (Group 4), and PH with unclear mechanisms (Group 5) (Olsson et al., 2023