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Not suitable for children under the age of 15 years old or pregnant women: should only be used under medical or dietetic supervision

[DOI] [PubMed] [Google Scholar] 28.Schafer F.Q., Buettner G.R

The metabolism and elimination of NAD+ (and its by-products) could be altered in advanced hepatic or renal dysfunction, and high-dose NAD+ might theoretically affect cardiovascular dynamics, so practitioners generally avoid or closely supervise NAD+ use in such settings