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Because Midazolam can also impact GABA (gamma-aminobutyric acid) (12), a neurotransmitter in the brain responsible for reducing neuronal excitability throughout the nervous system, magnesium supplementation may be helpful as it supports neurotransmitter balance and muscle relaxation (13)

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Whether peripheral cytokines penetrate the brain to induce a damaging microglial neuroinflammatory state and grey matter loss [15] or exert direct effects on synaptic development, function and survival is debated [16,17,18]

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