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They work in different pathways and actually complement each other

used in long-term human clinical trials Intravenous injection Used primarily for pharmacokinetic characterization and acute dosing studies in humans Intraperitoneal injection Standard route for chronic rodent studies

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Meanwhile, the formula takes dark spot correction a step further by pairing niacinamide with Melasyla proprietary ingredient designed to interfere with excess melanin production that contributes to hyperpigmentation