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The activation of the Nrf2 (nuclear factor erythroid-derived 2)/ARE (antioxidant response elements) pathway is likely a principal and underlying mechanism of hormesis, which can limit age-related damage, numerous disease processes progression, and induction of toxicities due to chemicals and radiations (70)

Neuroinflammation, driven by the activation of microglia, is another critical factor in PD pathogenesis

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This gap has led a growing number of people to look beyond the typical routetoward natural, science-informed alternatives