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The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (HFpEF)

To protect muscle during treatment: Encourage strength training and physical activity Ensure adequate protein intake Use tools to monitor body composition, not just weight This helps patients maintain functionality while still achieving the metabolic benefits of treatment

CACT acetylation mechanism is in line with a dynamic post-translational protein control that could undergo an on/off switch induced by deacetylation/acetylation linked to the availability of acetyl-CoA 57