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Many clinics now are helping some of these individuals engage in off-label use of the medication for weight loss, which can potentially harm their health in exchange for a quick way to drop a few pounds, which the research studies show will just return when you stop the shot

Common effects may include digestive discomfort or fatigue, which often lessen over time

The most significant published data come from a Phase 2 trial published in The New England Journal of Medicine (Jastreboff et al., 2023), which evaluated retatrutide across multiple doses in adults with obesity or overweight

These are not minor differences