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Cellular GSSG accumulation, as opposed to GSH reduction, rendered hepatocytes susceptible to TNF cytotoxicity Increased GSSG/GSG ratios in response to H 2 O 2 exposure can stem from both GSH reduction and GSSG accumulation (data not shown)

Chemokines recruit neutrophils to tumor sites, creating a microenvironment that favors cancer progression and adverse patient outcomes (172, 173)

p62 acts as a bridge between ubiquitinated proteins and the autophagic machinery, facilitating the degradation of ubiquitinated substrates via autophagy

Allowing endogenous myrosinase to act increases conversion of glucosinolates to isothiocyanates