Scott Butsch, director of obesity medicine at the Cleveland Clinic Bariatric and Metabolic Institute
The foods most likely to work against your GLP-1 therapy: Sugary beverages and foods juice, soda, candy, and sweetened coffee drinks cause rapid blood sugar spikes that counteract the medication's stabilizing effect Refined carbohydrates white bread, regular pasta, crackers, and pastries digest quickly and spike blood sugar in ways fiber-rich whole grains don't High-saturated-fat foods fried foods, fatty processed meats, and baked goods high in butter or shortening slow gastric emptying beyond what's therapeutic, which can worsen nausea and discomfort Can You Drink Alcohol While on GLP-1 Medications
More recently, the SELECT trial showed that semaglutide 2.4 mg reduced major adverse cardiovascular events in adults with overweight or obesity without diabetes
There may still be limited use under 503A compounding rules, where a medication is prepared for an individual patient based on a specific clinical indication, but that pathway is much more restricted and not designed for widespread use. Jen Manne-Goehler, MD, ScD,assistant professor of medicine at Harvard Medical School, agreed