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Symptoms such as hypotension, laryngeal edema or severe bronchospasm could be present but were not required for the case definition

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doi: 10.1016/S0140-6736(21)01919-X 72 De BlockCEMDirinckEVerhaegenAVan GaalLF

However, with the more recently introduced SGLT2 inhibitors and GLP-1 receptor agonists having shown impressive cardiovascular risk reduction in addition to glycemic control efficacy, these newer agents may also be considered as first-line therapies in patients with pre-existing cardiovascular or renal disease (Garber 2020)