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for example, salinomycin can drive ferroptosis-based cell death in breast CSCs (Zhao et al., 2019), and ironmycin, a derivative of salinomycin, can specifically trigger iron accumulation in lysosomes, activating cell death pathways consistent with ferroptosis (Mai et al., 2017)

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The reaction catalyzed by -ECS/GSH1 is considered the rate-controlling step of GSH synthesis, and the activity of this enzyme is regulated by cellular levels of cysteine and glutamic acid, and feedback inhibition by -EC and GSH ( Figure 1 GSH1 (EC 6.3.2.2) is exclusively present in plastids, while GSH2 (EC 6.3.2.2) has dual localization in plastids and the cytosol, both encoded by a single gene (Wachter et al., 2005)

In the research-peptide community it is studied for muscle satellite-cell activation and recovery , and is treated as the longer-acting version of MGF: attaching a polyethylene-glycol (PEG) chain slows clearance so it can be dosed a few times a week rather than only immediately post-workout