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10.1016/j.biopha.2020.110523 47 LillyE

This matters most in groups already vulnerable to changes in bone density, including: Post-menopausal women Adults over 50 Individuals with low resistance training exposure Athletes experiencing chronically low energy availability GLP-1 therapy is not contraindicated for these groups

The EXSCEL (NCT01144338), HARMONY (NCT02465515), REWIND ( NCT01394952), and AMPLITUDE-O (NCT03496298) trials all demonstrated cardioprotection or near misses for exenatide, albiglutide, dulaglutide and efpeglenatide, respectively

They mimic a natural gut hormone that regulates multiple metabolic processes simultaneously