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Additionally, studies should analyze the synergistic or antagonistic effects of LPS with other microbial metabolites (e.g., SCFAs, TMAO) in the OA microenvironment on ferroptosis regulation

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While correlative data such as these cannot establish causality, the observation that women are also more likely than men to discontinue these medications strengthens the interpretation that the efficacy-to-tolerability ratio for these drugs is lower for women (Fig