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Obesity, a growing global health concern, is linked to genetic, environmental, and lifestyle factors that increase the risk of chronic diseases such as type 2 diabetes, cardiovascular disease, common cancers, and osteoarthritis, as well as significantly increasing healthcare costs during childhood and adolescence

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PMID: 31790002

Hours after the initial trigger, mast cells produce and secrete certain chemokines (TNF, CCL2, CCL8) and renin.[ref] The different mediators released can lead to different symptoms of mast cell activation syndrome: Histamine leads to headaches, migraines, low blood pressure, itching, stomach acid release (and much more) Tryptase causes inflammation and fibrinogen lysis