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doi: 10.1210/er.2017-00211
Read the full article for deeper context and safety considerations: #GLP1 #ObesityCare #MedicationSafety #PatientAwareness #AJPHI To view or add a comment, sign in What is your favorite critical care topic
Alterations in mitochondrial functions such as oxidative phosphorylation (OXPHOS) and membrane polarity, which enhance oxidative stress and apoptosis, may precede the development of depressive symptoms [84, 88, 89]
With respect to hypertension, several in vivo studies have provided evidence that eNOS uncoupling occurs in animal models of increased blood pressure, including ATII hypertension, 14 DOCA-salt induced hypertension, 57 NOX1 upregulation 83 and genetically determined hypertension 84 in which an uncoupled eNOS was consistently identified as a significant superoxide source
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